Flight tickets from Knoxville to Santo Domingo

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Flight deals from Knoxville to Santo Domingo

Looking for a cheap last-minute deal or the best return flight from Knoxville Airport to Santo Domingo? If you want to travel next month, return fares start from ₹ 62,290. Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Knoxville to Santo Domingo

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Knoxville to Santo Domingo flights are currently cheapest in January.

Alternative Knoxville to Santo Domingo routes

Looking for the cheapest, fastest or easiest route from Knoxville to Santo Domingo? You could fly into the following airports instead.

Knoxville to Santo Domingo: Flight information

The things to know before you go.
Cheapest flight found₹ 30,623
Cheapest month to flyJanuary

Finding cheap flights from Knoxville to Santo Domingo: Frequently asked questions

There are 3 airports in Santo Domingo: La Isabela International, Santo Domingo Las Americas and Samana.
The best price we found for a return flight from Knoxville to Santo Domingo is ₹ 53,062. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Knoxville to Santo Domingo. But we found flights with one or more stops from ₹ 53,112.
As of July 2026, there are no flights flying from Knoxville to Santo Domingo.
The cheapest month to fly from Knoxville to Santo Domingo is usually August.
If you're flying from Knoxville Airport, the cheapest airport near Santo Domingo is Santo Domingo Las Americas – which is 23.4 km away from the centre of Santo Domingo. We've found flights into this airport from ₹ 53,062.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Knoxville Airport to Santo Domingo on Wednesday, 26 August 2026.
No airlines currently offer direct flights between Knoxville Airport and Santo Domingo. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santo Domingo but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Santo Domingo is around 40 days in advance, so don’t leave your flight to the last minute.

In July, the average temperature is usually around 28°C. August is typically the warmest month in Santo Domingo, when it usually averages around 31°C. You can expect the least rain in March. The coldest month is January, with temperatures averaging 21°C. The rainiest month is September.
Currently, Delta offers the cheapest flight tickets to Santo Domingo.

Flying from Knoxville McGhee Tyson Airport (TYS) to Santo Domingo: what you need to know

  • Knoxville McGhee Tyson Airport is located in Knoxville. Based in the UTC-4 timezone, Santo Domingo is one hour ahead of Knoxville.

  • For a stress-free journey, turn up at the airport two hours ahead of international flights and an hour before domestic departures. This leaves you with plenty of time to board your TYS to Santo Domingo flight.

  • During popular months like June, it's wise to get to the airport even earlier. Arrive two hours before domestic departures and four hours ahead for an international flight when you fly during high season in general.

  • The journey from central Knoxville to TYS takes around 50 minutes on public transport. If you drive, ride-share or take a taxi, you'll cover the 18 kilometres in 25 minutes or so, depending on traffic conditions.

  • In search of a hotel close to TYS? If you're catching an early flight from Knoxville McGhee Tyson Airport to Santo Domingo, these stays will put you moments from check-in:

  • When it comes to Knoxville McGhee Tyson Airport's on-time performance, data shows 76% of flights complete their journey on time.

  • TYS is located at 2055 Alcoa Highway.

How to find the cheapest flights from Knoxville McGhee Tyson Airport (TYS) to Santo Domingo

  • ₹ 30,623 is currently the best price for a one-way Knoxville McGhee Tyson Airport to Santo Domingo flight. A return plane ticket starts from ₹ 53,062. These fares may change depending on availability and demand.

  • Booking early is often the key to locking in a cheap flight from TYS to Santo Domingo. Fares tend to rise as demand increases, so the closer your departure date, the more you'll likely pay.

  • The 'Whole month' tool will show you the cheapest tickets from Knoxville McGhee Tyson Airport to Santo Domingo across the entire month. It's an easy way to find a bargain if your travel plans aren't set in stone.

  • There's no need to check in daily to find out if fares have dropped when you create a Price Alert. We'll let you know as soon as there's an updated deal for cheap flights from TYS to Santo Domingo.

  • Save on your flight from Knoxville McGhee Tyson Airport to Santo Domingo with the help of our filters. Choose your preferred duration, number of stops and airlines, then sort the results by 'Cheapest' for the best deals.

Airports in Santo Domingo

Santo Domingo Las Americas International Airport (SDQ)

  • The distance from Santo Domingo Las Americas International Airport (SDQ) to central Santo Domingo is roughly 29 kilometres. It takes about 35 minutes to get to the centre driving.

  • Getting there by public transport takes around 1 hour 15 minutes.

  • The last thing you need is a long journey to your hotel if you're landing late on a flight from Knoxville McGhee Tyson Airport to Santo Domingo. Stay at one of these accommodation options near SDQ instead:

  • Reserving your ride from Santo Domingo Las Americas International Airport about one week in advance of your flight from TYS to Santo Domingo can help you lock in the lowest rate.

La Isabela Dr Joaquin Balaguer Intl Airport (JBQ)

  • La Isabela Dr Joaquin Balaguer Intl Airport (JBQ) is around 23 kilometres from central Santo Domingo. After your flight from Knoxville McGhee Tyson Airport to Santo Domingo, it'll take you around 30 minutes to get to the heart of the city in a taxi or ride-share.

  • Travelling by public transport will take around 50 minutes.

  • You'll find some great places to call home for the night near JBQ. Kick back and get cosy after your TYS to Santo Domingo flight at one of these well-located options:

  • Get your ideal vehicle, not just what's left, by securing your ride from JBQ ahead of your arrival. You can also avoid paying extra, especially during busy airport times.

Best time to go to Santo Domingo

  • It's time to choose your dates for your flight from Knoxville McGhee Tyson Airport to Santo Domingo. August is the most popular month to travel to Santo Domingo. If you want a more peaceful vibe, go in December.

  • The warmest month in Santo Domingo is September, with temperatures ranging between 23ºC and 33ºC. Book your Knoxville McGhee Tyson Airport to Santo Domingo plane ticket then if that's your ideal forecast.

  • February sees average temperatures of between 19ºC and 29ºC. Search for a cheap ticket from TYS to Santo Domingo around that time if you'd rather travel in cooler conditions.

More about Santo Domingo

  • Once you've booked your flight from Knoxville McGhee Tyson Airport to Santo Domingo, choose a hotel that puts you right where the action is. Make one of these options your base for exploring Santo Domingo:

  • There are so many things to see and do in this city it can be difficult to know where to start. Alcazar de Colon, Catedral Primada de las Americas and The Cathedral of the Americas are leading attractions which should feature on every Santo Domingo itinerary.

Explore more of the Dominican Republic

  • La Romana is just one of the many cities in the Dominican Republic waiting to be discovered once you've seen the sights of Santo Domingo. Around 105 kilometres away to the east, popular attractions include Altos de Chavon, Minitas Beach and Dye Fore Golf Course of Casa de Campo.

  • If you want to check out another corner of the Dominican Republic, head for Puerto Plata, roughly 161 kilometres northwest of Santo Domingo. Long Beach, Golden Beach (Playa Dorada) and Puerto Plata Cable Car are the start of reasons to visit.

Prices shown on this page are estimated lowest prices only. Found in the last 12 days.